SARS-CoV spike protein-expressing recombinant vaccinia virus efficiently induces neutralizing antibodies in rabbits pre-immunized with vaccinia virus
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Auteurs : Masahiro Kitabatake [Japon] ; Shingo Inoue [Japon] ; Fumihiko Yasui [Japon] ; Shoji Yokochi [Japon] ; Masaaki Arai [Japon] ; Kouichi Morita [Japon] ; Hisatoshi Shida [Japon] ; Minoru Kidokoro [Japon] ; Fukashi Murai [Japon] ; Mai Quynh Le [Viêt Nam] ; Kyosuke Mizuno [Japon] ; Kouji Matsushima [Japon] ; Michinori Kohara [Japon]Source :
- Vaccine [ 0264-410X ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Anticorps antiviraux (sang), Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (génétique), Glycoprotéines membranaires (immunologie), Immunisation, Lapins, Protéines de l'enveloppe virale (génétique), Protéines de l'enveloppe virale (immunologie), Régulation de l'expression des gènes viraux, Tests de neutralisation, Virus de la vaccine (génétique), Virus du SRAS (génétique), Virus du SRAS (immunologie).
- MESH :
- génétique : Glycoprotéines membranaires, Protéines de l'enveloppe virale, Virus de la vaccine, Virus du SRAS.
- immunologie : Anticorps antiviraux, Glycoprotéines membranaires, Protéines de l'enveloppe virale, Virus du SRAS.
- sang : Anticorps antiviraux.
- Animaux, Glycoprotéine de spicule des coronavirus, Immunisation, Lapins, Régulation de l'expression des gènes viraux, Tests de neutralisation.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (blood), Antibodies, Viral (immunology), Gene Expression Regulation, Viral, Immunization, Membrane Glycoproteins (genetics), Membrane Glycoproteins (immunology), Neutralization Tests, Rabbits, SARS Virus (genetics), SARS Virus (immunology), Spike Glycoprotein, Coronavirus, Vaccinia virus (genetics), Viral Envelope Proteins (genetics), Viral Envelope Proteins (immunology).
- MESH :
- chemical , blood : Antibodies, Viral.
- chemical , genetics : Membrane Glycoproteins, Viral Envelope Proteins.
- chemical , immunology : Antibodies, Viral, Membrane Glycoproteins, Viral Envelope Proteins.
- genetics : SARS Virus, Vaccinia virus.
- immunology : SARS Virus.
- Animals, Gene Expression Regulation, Viral, Immunization, Neutralization Tests, Rabbits, Spike Glycoprotein, Coronavirus.
Abstract
A vaccine for severe acute respiratory syndrome (SARS) is being intensively pursued against its re-emergence. We generated a SARS coronavirus (SARS-CoV) spike protein-expressing recombinant vaccinia virus (RVV-S) using highly attenuated strain LC16m8. Intradermal administration of RVV-S into rabbits induced neutralizing (NT) antibodies against SARS-CoV 1 week after administration and the NT titer reached 1:1000 after boost immunization with RVV-S. Significantly, NT antibodies against SARS-CoV were induced by administration of RVV-S to rabbits that had been pre-immunized with LC16m8. RVV-S can induce NT antibodies against SARS-CoV despite the presence of NT antibodies against VV. These results suggest that RVV-S may be a powerful SARS vaccine, including in patients previously immunized with the smallpox vaccine.
Url:
DOI: 10.1016/j.vaccine.2006.08.039
PubMed: 17011679
PubMed Central: 7115632
Affiliations:
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Le document en format XML
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neutralizing antibodies in rabbits pre-immunized with vaccinia virus</title><author><name sortKey="Kitabatake, Masahiro" sort="Kitabatake, Masahiro" uniqKey="Kitabatake M" first="Masahiro" last="Kitabatake">Masahiro Kitabatake</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Microbiology and Cell Biology, The Tokyo Metropolitan Institute of Medical Science, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology and Cell Biology, The Tokyo Metropolitan Institute of Medical Science, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113-8613</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Department of Molecular Preventive Medicine, School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Molecular Preventive Medicine, School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Inoue, Shingo" sort="Inoue, Shingo" uniqKey="Inoue S" first="Shingo" last="Inoue">Shingo Inoue</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4, Sakamoto, Nagasaki 852-8523, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4, Sakamoto, Nagasaki 852-8523</wicri:regionArea><wicri:noRegion>Nagasaki 852-8523</wicri:noRegion></affiliation></author><author><name sortKey="Yasui, Fumihiko" sort="Yasui, Fumihiko" uniqKey="Yasui F" first="Fumihiko" last="Yasui">Fumihiko Yasui</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Microbiology and Cell Biology, The Tokyo Metropolitan Institute of Medical Science, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology and Cell Biology, The Tokyo Metropolitan Institute of Medical Science, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113-8613</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Yokochi, Shoji" sort="Yokochi, Shoji" uniqKey="Yokochi S" first="Shoji" last="Yokochi">Shoji Yokochi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Microbiology and Cell Biology, The Tokyo Metropolitan Institute of Medical Science, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology and Cell Biology, The Tokyo Metropolitan Institute of Medical Science, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113-8613</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Post Genome Institute Co., Ltd., 3-38-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Post Genome Institute Co., Ltd., 3-38-1, Hongo, Bunkyo-ku, Tokyo 113-0033</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Arai, Masaaki" sort="Arai, Masaaki" uniqKey="Arai M" first="Masaaki" last="Arai">Masaaki Arai</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Microbiology and Cell Biology, The Tokyo Metropolitan Institute of Medical Science, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology and Cell Biology, The Tokyo Metropolitan Institute of Medical Science, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113-8613</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Pharmaceuticals Research Unit, Research & Development Division, Mitsubishi Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Pharmaceuticals Research Unit, Research & Development Division, Mitsubishi Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama 227-0033</wicri:regionArea><wicri:noRegion>Yokohama 227-0033</wicri:noRegion></affiliation></author><author><name sortKey="Morita, Kouichi" sort="Morita, Kouichi" uniqKey="Morita K" first="Kouichi" last="Morita">Kouichi Morita</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4, Sakamoto, Nagasaki 852-8523, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Virology, Institute of Tropical Medicine, Nagasaki University, 1-12-4, Sakamoto, Nagasaki 852-8523</wicri:regionArea><wicri:noRegion>Nagasaki 852-8523</wicri:noRegion></affiliation></author><author><name sortKey="Shida, Hisatoshi" sort="Shida, Hisatoshi" uniqKey="Shida H" first="Hisatoshi" last="Shida">Hisatoshi Shida</name><affiliation wicri:level="1"><nlm:aff id="aff6">Division of Molecular Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo 060-0815, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Molecular Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo 060-0815</wicri:regionArea><wicri:noRegion>Sapporo 060-0815</wicri:noRegion></affiliation></author><author><name sortKey="Kidokoro, Minoru" sort="Kidokoro, Minoru" uniqKey="Kidokoro M" first="Minoru" last="Kidokoro">Minoru Kidokoro</name><affiliation wicri:level="1"><nlm:aff id="aff7">Third Department of Virology, National Institute of Infectious Diseases, 4-7-1, Gakuen, Musashimurayama 208-0011, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Third Department of Virology, National Institute of Infectious Diseases, 4-7-1, Gakuen, Musashimurayama 208-0011</wicri:regionArea><wicri:noRegion>Musashimurayama 208-0011</wicri:noRegion></affiliation></author><author><name sortKey="Murai, Fukashi" sort="Murai, Fukashi" uniqKey="Murai F" first="Fukashi" last="Murai">Fukashi Murai</name><affiliation wicri:level="1"><nlm:aff id="aff4">Post Genome Institute Co., Ltd., 3-38-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Post Genome Institute Co., Ltd., 3-38-1, Hongo, Bunkyo-ku, Tokyo 113-0033</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Le, Mai Quynh" sort="Le, Mai Quynh" uniqKey="Le M" first="Mai Quynh" last="Le">Mai Quynh Le</name><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Virology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Department of Virology, National Institute of Hygiene and Epidemiology, Hanoi</wicri:regionArea><wicri:noRegion>Hanoi</wicri:noRegion></affiliation></author><author><name sortKey="Mizuno, Kyosuke" sort="Mizuno, Kyosuke" uniqKey="Mizuno K" first="Kyosuke" last="Mizuno">Kyosuke Mizuno</name><affiliation wicri:level="1"><nlm:aff id="aff9">The Chemo-Sero-Therapeutic Research Institute, 1-6-1, Okubo, Kumamoto 860-8568, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>The Chemo-Sero-Therapeutic Research Institute, 1-6-1, Okubo, Kumamoto 860-8568</wicri:regionArea><wicri:noRegion>Kumamoto 860-8568</wicri:noRegion></affiliation></author><author><name sortKey="Matsushima, Kouji" sort="Matsushima, Kouji" uniqKey="Matsushima K" first="Kouji" last="Matsushima">Kouji Matsushima</name><affiliation wicri:level="4"><nlm:aff id="aff2">Department of Molecular Preventive Medicine, School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Molecular Preventive Medicine, School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Kohara, Michinori" sort="Kohara, Michinori" uniqKey="Kohara M" first="Michinori" last="Kohara">Michinori Kohara</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Microbiology and Cell Biology, The Tokyo Metropolitan Institute of Medical Science, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Microbiology and Cell Biology, The Tokyo Metropolitan Institute of Medical Science, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113-8613</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><idno type="eISSN">1873-2518</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (blood)</term><term>Antibodies, Viral (immunology)</term><term>Gene Expression Regulation, Viral</term><term>Immunization</term><term>Membrane Glycoproteins (genetics)</term><term>Membrane Glycoproteins (immunology)</term><term>Neutralization Tests</term><term>Rabbits</term><term>SARS Virus (genetics)</term><term>SARS Virus (immunology)</term><term>Spike Glycoprotein, Coronavirus</term><term>Vaccinia virus (genetics)</term><term>Viral Envelope Proteins (genetics)</term><term>Viral Envelope Proteins (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (immunologie)</term><term>Anticorps antiviraux (sang)</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires (génétique)</term><term>Glycoprotéines membranaires (immunologie)</term><term>Immunisation</term><term>Lapins</term><term>Protéines de l'enveloppe virale (génétique)</term><term>Protéines de l'enveloppe virale (immunologie)</term><term>Régulation de l'expression des gènes viraux</term><term>Tests de neutralisation</term><term>Virus de la vaccine (génétique)</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Glycoproteins</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term><term>Membrane Glycoproteins</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term><term>Vaccinia virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéines membranaires</term><term>Protéines de l'enveloppe virale</term><term>Virus de la vaccine</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Glycoprotéines membranaires</term><term>Protéines de l'enveloppe virale</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Gene Expression Regulation, Viral</term><term>Immunization</term><term>Neutralization Tests</term><term>Rabbits</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Glycoprotéine de spicule des coronavirus</term><term>Immunisation</term><term>Lapins</term><term>Régulation de l'expression des gènes viraux</term><term>Tests de neutralisation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A vaccine for severe acute respiratory syndrome (SARS) is being intensively pursued against its re-emergence. We generated a SARS coronavirus (SARS-CoV) spike protein-expressing recombinant vaccinia virus (RVV-S) using highly attenuated strain LC16m8. Intradermal administration of RVV-S into rabbits induced neutralizing (NT) antibodies against SARS-CoV 1 week after administration and the NT titer reached 1:1000 after boost immunization with RVV-S. Significantly, NT antibodies against SARS-CoV were induced by administration of RVV-S to rabbits that had been pre-immunized with LC16m8. RVV-S can induce NT antibodies against SARS-CoV despite the presence of NT antibodies against VV. These results suggest that RVV-S may be a powerful SARS vaccine, including in patients previously immunized with the smallpox vaccine.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S. 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Sexton</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li><li>Viêt Nam</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement><orgName><li>Université de Tokyo</li></orgName></list><tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Kitabatake, Masahiro" sort="Kitabatake, Masahiro" uniqKey="Kitabatake M" first="Masahiro" last="Kitabatake">Masahiro Kitabatake</name></region><name sortKey="Arai, Masaaki" sort="Arai, Masaaki" uniqKey="Arai M" first="Masaaki" last="Arai">Masaaki Arai</name><name sortKey="Arai, Masaaki" sort="Arai, Masaaki" uniqKey="Arai M" first="Masaaki" last="Arai">Masaaki Arai</name><name sortKey="Inoue, Shingo" sort="Inoue, Shingo" uniqKey="Inoue S" first="Shingo" last="Inoue">Shingo Inoue</name><name sortKey="Kidokoro, Minoru" sort="Kidokoro, Minoru" uniqKey="Kidokoro M" first="Minoru" last="Kidokoro">Minoru Kidokoro</name><name sortKey="Kitabatake, Masahiro" sort="Kitabatake, Masahiro" uniqKey="Kitabatake M" first="Masahiro" last="Kitabatake">Masahiro Kitabatake</name><name sortKey="Kohara, Michinori" sort="Kohara, Michinori" uniqKey="Kohara M" first="Michinori" last="Kohara">Michinori Kohara</name><name sortKey="Matsushima, Kouji" sort="Matsushima, Kouji" uniqKey="Matsushima K" first="Kouji" last="Matsushima">Kouji Matsushima</name><name sortKey="Mizuno, Kyosuke" sort="Mizuno, Kyosuke" uniqKey="Mizuno K" first="Kyosuke" last="Mizuno">Kyosuke Mizuno</name><name sortKey="Morita, Kouichi" sort="Morita, Kouichi" uniqKey="Morita K" first="Kouichi" last="Morita">Kouichi Morita</name><name sortKey="Murai, Fukashi" sort="Murai, Fukashi" uniqKey="Murai F" first="Fukashi" last="Murai">Fukashi Murai</name><name sortKey="Shida, Hisatoshi" sort="Shida, Hisatoshi" uniqKey="Shida H" first="Hisatoshi" last="Shida">Hisatoshi Shida</name><name sortKey="Yasui, Fumihiko" sort="Yasui, Fumihiko" uniqKey="Yasui F" first="Fumihiko" last="Yasui">Fumihiko Yasui</name><name sortKey="Yokochi, Shoji" sort="Yokochi, Shoji" uniqKey="Yokochi S" first="Shoji" last="Yokochi">Shoji Yokochi</name><name sortKey="Yokochi, Shoji" sort="Yokochi, Shoji" uniqKey="Yokochi S" first="Shoji" last="Yokochi">Shoji Yokochi</name></country><country name="Viêt Nam"><noRegion><name sortKey="Le, Mai Quynh" sort="Le, Mai Quynh" uniqKey="Le M" first="Mai Quynh" last="Le">Mai Quynh Le</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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